Fast-Acting Relief for Treatment-Resistant Depression
Spravato® (esketamine) offers a breakthrough option for adults who haven’t found success with traditional antidepressants—delivering relief where other treatments may have failed.
What Is Spravato?
Spravato® is an FDA-approved nasal spray medication derived from ketamine, designed specifically for adults with treatment-resistant depression (TRD). Unlike oral antidepressants that can take weeks to work, Spravato begins acting on symptoms within hours to days—helping you feel better, faster. Administered in a clinical setting, Spravato is always used alongside an oral antidepressant for maximum effectiveness.
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70% of patients saw a significant reduction in depressive symptoms after four weeks of treatment with Spravato, alongside an oral antidepressant.
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In a long-term clinical trial, patients using Spravato were 51% less likely to relapse compared to those on oral antidepressants alone.
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Spravato works on the brain’s glutamate system—a different pathway than most antidepressants—making it effective when others haven’t been.
Real People.
Really Inspiring Stories
Grace’s Story
Introducing Grace, a courageous 29-year-old graphic designer from Colorado who has treatment-resistant depression. Throughout college, Grace felt isolated and struggled to share her inner turmoil with others. Despite trying multiple antidepressants, nothing seemed to help. However, Grace’s journey took a hopeful turn when she learned about SPRAVATO®
Karen’s Story
Meet Karen, a brave woman from the Latin community located in Chicago, who has treatment-resistant depression. Karen had tried multiple antidepressants before her psychiatrist recommended a different approach: SPRAVATO®. Learn more about Karen’s SPRAVATO® treatment story and her experience with treatment-resistant depression in this video.
Nicole's Story
Meet Nicole, a 23-year-old from Missouri who has treatment-resistant depression, leading to difficulties in her daily life as a college student and daughter. After trying multiple treatments without success, Nicole found SPRAVATO®.
Ben’s Story
Get to know Ben, a 40-year-old from New York who has treatment-resistant depression. His internal struggles led to feelings of worthlessness and isolation, affecting his daily life. Ben had tried multiple antidepressants before his psychiatrist recommended SPRAVATO®.
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