Fast-Acting Relief for Treatment-Resistant Depression

Spravato® (esketamine) offers a breakthrough option for adults who haven’t found success with traditional antidepressants—delivering relief where other treatments may have failed.

What Is Spravato?

Spravato® is an FDA-approved nasal spray medication derived from ketamine, designed specifically for adults with treatment-resistant depression (TRD). Unlike oral antidepressants that can take weeks to work, Spravato begins acting on symptoms within hours to days—helping you feel better, faster. Administered in a clinical setting, Spravato is always used alongside an oral antidepressant for maximum effectiveness.

70% of patients saw a significant reduction in depressive symptoms after four weeks of treatment with Spravato, alongside an oral antidepressant.

In a long-term clinical trial, patients using Spravato were 51% less likely to relapse compared to those on oral antidepressants alone.

Spravato works on the brain’s glutamate system—a different pathway than most antidepressants—making it effective when others haven’t been.

Real People.
Really Inspiring Stories

Grace’s Story

Introducing Grace, a courageous 29-year-old graphic designer from Colorado who has treatment-resistant depression. Throughout college, Grace felt isolated and struggled to share her inner turmoil with others. Despite trying multiple antidepressants, nothing seemed to help. However, Grace’s journey took a hopeful turn when she learned about SPRAVATO®

Karen’s Story
Meet Karen, a brave woman from the Latin community located in Chicago, who has treatment-resistant depression. Karen had tried multiple antidepressants before her psychiatrist recommended a different approach: SPRAVATO®. Learn more about Karen’s SPRAVATO® treatment story and her experience with treatment-resistant depression in this video.

Nicole's Story

Meet Nicole, a 23-year-old from Missouri who has treatment-resistant depression, leading to difficulties in her daily life as a college student and daughter. After trying multiple treatments without success, Nicole found SPRAVATO®.

Ben’s Story
Get to know Ben, a 40-year-old from New York who has treatment-resistant depression. His internal struggles led to feelings of worthlessness and isolation, affecting his daily life. Ben had tried multiple antidepressants before his psychiatrist recommended SPRAVATO®.

Learn More About Spravato

Download Our Spravato Patient Brochure

Curious about how Spravato® works and whether it’s right for you?

Our Spravato® Patient Brochure offers an in-depth look at the treatment process, benefits, safety guidelines, and what to expect during your sessions at Transcendence.

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