A Breakthrough for Treatment-Resistant Depression
If you or someone you care about has been battling depression with little to no relief from traditional medications or therapy, you’re not alone - and there is hope.
At Transcendence, we offer Spratavo TM and IV Ketamine infusion therapy designed specifically for individuals with treatment-resistant depression.
If you're ready for a new path forward, we’re here to help.
What Is Treatment-Resistant Depression?
Depression is the most commonly diagnosed mental health condition in the U.S., affecting over 15 million people each year.
Treatment-Resistant Depression (TRD) refers to depression that doesn't improve after trying standard antidepressant therapies. Nearly half of all individuals diagnosed with depression fall into this category.
The good news? Innovative treatments like ketamine therapy are offering new hope for those who haven't found relief—until now.
Are Ketamine Infusions Effective for Treatment-Resistant Depression?
Over the past two decades, research has consistently shown that low-dose ketamine infusions can bring fast, powerful relief to individuals struggling with depression, especially when other treatments have failed.
Unlike traditional antidepressants, which can take weeks to work (if at all), ketamine often begins improving mood and mental clarity within hours. It addresses a wide range of symptoms common in treatment-resistant depression, including:
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Lack of pleasure or motivation (anhedonia)
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Anxiety and PTSD-related symptoms
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Suicidal thoughts and intrusive thinking
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Overall quality of life
One of ketamine’s most important effects is its ability to rapidly reduce—or even eliminate—suicidal ideation. In one study, 69% of participants experienced complete relief from suicidal thoughts after a course of repeated infusions.
For many patients with treatment-resistant depression, ketamine represents a life-changing breakthrough when nothing else has worked.
How Do Ketamine Infusions Work for Depression?
Ketamine stands apart from traditional antidepressants by working in a completely different—and much broader—way. Rather than targeting just serotonin or dopamine, ketamine interacts with multiple brain receptors and regions, giving it a wider range of therapeutic effects.
Research suggests that ketamine triggers a rapid surge in glutamate, a key neurotransmitter involved in mood regulation and brain function—believed to be central to its powerful antidepressant effects.
But ketamine doesn’t just provide symptom relief—it helps the brain heal. Functional MRI (fMRI) scans have shown that ketamine stimulates the growth of new neural connections and repairs damaged pathways in the brain. These changes, referred to as “synaptic plasticity,” can begin within just hours of treatment.
This regenerative effect is what makes ketamine such a promising breakthrough—offering more than just short-term relief, but the potential for long-term transformation.
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